Department of Laboratory Medicine, Tib Neeg Lub Tsev Kho Mob ntawm Guangxi Zhuang Autonomous Region, Nanning, Suav
Department of Laboratory Medicine, Affiliated Tsev Kho Mob ntawm Shandong University of Traditional suav tshuaj, Jinan
Huang Huayi, Tsev Kawm Ntawv Tshuaj Kho Mob, Youjiang National Medical University, Baise, Guangxi, 533000, Mindray North America, Mahwah, New Jersey, 07430, USA.
Department of Laboratory Medicine, Tib Neeg Lub Tsev Kho Mob ntawm Guangxi Zhuang Autonomous Region, Nanning, Suav
Department of Laboratory Medicine, Affiliated Tsev Kho Mob ntawm Shandong University of Traditional suav tshuaj, Jinan
Huang Huayi, Tsev Kawm Ntawv Tshuaj Kho Mob, Youjiang National Medical University, Baise, Guangxi, 533000, Mindray North America, Mahwah, New Jersey, 07430, USA.
Siv qhov txuas hauv qab no los qhia tag nrho cov ntawv nyeem ntawm kab lus no nrog koj cov phooj ywg thiab cov npoj yaig.Kawm ntxiv.
Txhawm rau kom nkag siab zoo dua cov kev hloov pauv pathological ntawm COVID-19, nws yog qhov tsim nyog rau kev tswj hwm kev kho mob ntawm tus kab mob thiab npaj rau nthwv dej ntawm kev sib kis zoo sib xws yav tom ntej.
Cov kab mob hematological ntawm 52 COVID-19 cov neeg mob tau txais mus rau hauv tsev kho mob tau raug tshuaj xyuas rov qab.Cov ntaub ntawv tau txheeb xyuas siv SPSS statistical software.
Ua ntej kev kho mob, T cell subsets, tag nrho cov lymphocytes, ntshav liab faib dav dav (RDW), eosinophils thiab basophils tau qis dua tom qab kev kho mob, thaum qhov ntsuas qhov mob ntawm neutrophils, neutrophils thiab lymphocytes Qhov ratio (NLR) thiab C β-reactive protein ( CRP) qib nrog rau cov qe ntshav liab (RBC) thiab hemoglobin poob qis tom qab kho.T cell subsets, tag nrho cov lymphocytes thiab basophils ntawm cov neeg mob hnyav thiab mob hnyav tau qis dua cov neeg mob nruab nrab.Neutrophils, NLR, eosinophils, procalcitonin (PCT) thiab CRP yog qhov tseem ceeb hauv cov neeg mob hnyav thiab mob hnyav dua li cov neeg mob nruab nrab.CD3+, CD8+, tag nrho cov lymphocytes, platelets, thiab basophils ntawm cov neeg mob hnub nyoog tshaj 50 xyoo yog qis dua cov hnub nyoog qis dua 50 xyoo, thaum neutrophils, NLR, CRP, RDW hauv cov neeg mob hnub nyoog tshaj 50 xyoo yog siab dua cov hnub nyoog qis dua 50 xyoo.Hauv cov neeg mob hnyav thiab mob hnyav, muaj kev sib raug zoo ntawm lub sijhawm prothrombin (PT), alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST).
T cell subsets, lymphocyte suav, RDW, neutrophils, eosinophils, NLR, CRP, PT, ALT thiab AST yog cov cim tseem ceeb hauv kev tswj hwm, tshwj xeeb tshaj yog rau cov neeg mob hnyav thiab mob hnyav nrog COVID-19.
Xyoo 2019 Tus Kab Mob Coronavirus (COVID-19) kis thoob qhov txhia chaw tshwm sim los ntawm ib yam tshiab ntawm tus mob coronavirus tau tshwm sim thaum lub Kaum Ob Hlis 2019 thiab kis mus thoob plaws ntiaj teb.1-3 Thaum pib ntawm qhov tshwm sim, qhov chaw kho mob tsom mus rau qhov tshwm sim thiab kis kab mob, ua ke nrog kev suav tomography rau cov neeg mob cov duab 4 thiab 5, thiab tom qab ntawd kuaj pom cov txiaj ntsig zoo nucleotide amplification.Txawm li cas los xij, ntau yam kev raug mob pathological tau pom tom qab hauv cov kabmob sib txawv.6-9 Ntau thiab ntau cov pov thawj qhia tias kev hloov pauv pathophysiological ntawm COVID-19 yog qhov nyuaj dua.Tus kab mob tua kab mob ua rau ntau lub cev puas tsuaj thiab lub cev tiv thaiv kab mob overreacts.Kev nce hauv cov ntshav thiab alveolar cytokines thiab inflammatory teb cov proteins tau pom 7, 10-12, thiab lymphopenia thiab txawv txav T cell subsets tau pom nyob rau hauv cov neeg mob hnyav.13, 14 Nws tau tshaj tawm tias qhov sib piv ntawm neutrophils rau lymphocytes tau dhau los ua qhov taw qhia tseem ceeb rau kev paub qhov txawv ntawm cov qog nqaij hlav qog nqaij hlav thiab benign thyroid hauv kev kho mob.15 NLR kuj tseem tuaj yeem pab cais cov neeg mob uas muaj kab mob plab ulcerative los ntawm kev noj qab haus huv.16 Nws kuj ua lub luag haujlwm hauv thyroiditis thiab cuam tshuam nrog hom 2 mob ntshav qab zib.17, 18 RDW yog ib qho cim ntawm erythrocytosis.Cov kev tshawb fawb tau pom tias nws pab kom paub qhov txawv cov thyroid nodules, kuaj mob rheumatoid mob caj dab, kab mob lumbar disc, thiab thyroiditis.19-21 CRP yog ib qho kev kwv yees thoob ntiaj teb ntawm kev mob thiab tau kawm ntau zaus.22 Tsis ntev los no tau tshawb pom tias NLR, RDW thiab CRP kuj tau koom nrog COVID-19 thiab ua lub luag haujlwm tseem ceeb hauv kev kuaj mob thiab ntsuas tus kabmob.11, 14, 23-25 Yog li ntawd, cov txiaj ntsig ntawm kev kuaj sim yog qhov tseem ceeb rau kev ntsuas tus neeg mob thiab txiav txim siab txog kev kho mob.Peb rov qab txheeb xyuas qhov ntsuas qhov ntsuas ntawm 52 tus neeg mob COVID-19 uas tau mus pw hauv tsev kho mob hauv tsev kho mob hauv South Tuam Tshoj raws li lawv cov kev kho ua ntej thiab tom qab kev kho mob, qhov hnyav, thiab hnub nyoog, kom nkag siab ntxiv txog kev hloov pauv ntawm tus kab mob thiab pab tswj kev kho mob yav tom ntej. ntawm COVID-19.
Txoj kev tshawb no tau tshawb xyuas rov qab los ntawm 52 tus neeg mob COVID-19 tau mus rau hauv tsev kho mob Nanning Fourth Hospital txij thaum Lub Ib Hlis 24, 2020 txog rau Lub Peb Hlis 2, 2020. Ntawm lawv, 45 tus neeg mob hnyav thiab 5 tus mob hnyav.Piv txwv li, muaj hnub nyoog li ntawm 3 lub hlis mus rau 85 xyoo.Hais txog poj niam txiv neej, muaj 27 txiv neej thiab 25 poj niam.Tus neeg mob muaj cov tsos mob xws li kub taub hau, hnoos qhuav, qaug zog, mob taub hau, ua tsis taus pa, qhov ntswg congestion, los ntswg, mob caj pas, mob nqaij, raws plab, thiab myalgia.Kev suav tomography pom tau tias lub ntsws yog patchy lossis iav av, qhia tias mob ntsws.Kev kuaj mob raws li 7th ib tsab ntawm Suav COVID-19 Kev kuaj mob thiab cov lus qhia txog kev kho mob.Kev lees paub los ntawm lub sijhawm tiag tiag qPCR kuaj pom tus kab mob nucleotides.Raws li cov txheej txheem kuaj mob, cov neeg mob tau muab faib ua pawg nruab nrab, mob hnyav, thiab tseem ceeb.Hauv cov xwm txheej nruab nrab, tus neeg mob ua npaws thiab ua pa ua pa, thiab cov kev tshawb pom pom pom cov qauv mob ntsws.Yog tias tus neeg mob ua tau raws li cov qauv hauv qab no, qhov kev kuaj mob hnyav heev: (a) ua pa nyuaj (ua pa ≥30 pa / min);(b) so ntiv tes ntshav oxygen saturation ≤93%;(c) arterial oxygen siab (PO2) )/Inspiratory feem O2 (Fi O2) ≤300 mm Hg (1 mm Hg = 0.133 kPa).Yog tias tus neeg mob ua tau raws li cov qauv hauv qab no, qhov kev kuaj mob hnyav heev: (a) ua pa tsis ua haujlwm uas yuav tsum tau siv tshuab ua pa;(b) poob siab;(c) Lwm yam kabmob tsis ua haujlwm uas xav tau kev kho mob hauv tsev kho mob hnyav (ICU).Raws li cov txheej txheem saum toj no, 52 tus neeg mob tau kuaj pom tias mob hnyav hauv 2 tus neeg mob, mob hnyav ntawm 5 tus neeg mob, thiab mob me me hauv 45 tus neeg mob.
Txhua tus neeg mob, suav nrog cov neeg mob nruab nrab, mob hnyav thiab mob hnyav, raug kho raws li cov txheej txheem hauv qab no: (a) Kev kho dav dav dav dav;(b) Antiviral therapy: lopinavir / ritonavir thiab α-interferon;(c) Qhov ntau npaum ntawm cov tshuaj suav tshuaj suav tuaj yeem hloov kho raws li tus neeg mob tus mob.
Txoj kev tshawb no tau pom zoo los ntawm Pawg Saib Xyuas Kev Tshawb Fawb ntawm Lub Tsev Haujlwm Saib Xyuas Kev Tshawb Fawb ntawm Nanning Fourth Hospital thiab tau siv los sau cov ntaub ntawv tus neeg mob.
Peripheral ntshav hematology tsom xam: niaj hnub hematology tsom xam ntawm cov ntshav peripheral yog ua ntawm Mindray BC-6900 hematology analyzer (Mindray) thiab Sysmex XN 9000 hematology analyzer (Sysmex).Kev yoo mov ethylenediaminetetraacetic acid (EDTA) anticoagulant ntshav kuaj tau sau thaum sawv ntxov tom qab tus neeg mob tau mus rau hauv tsev kho mob.Qhov kev ntsuam xyuas tsis sib xws ntawm ob lub ntsuas ntshav saum toj no tau txheeb xyuas raws li cov txheej txheem kuaj xyuas kom zoo.Hauv kev txheeb xyuas hematology, cov qe ntshav dawb (WBC) suav thiab sib txawv, cov qe ntshav liab (RBC) thiab qhov ntsuas tau tau ua ke nrog cov phiaj xwm tawg thiab cov histograms.
Flow cytometry ntawm T lymphocyte subpopulations: BD (Becton, Dickinson thiab tuam txhab) FACSCalibur flow cytometer tau siv rau kev ntsuas cytometry los txheeb xyuas T cell subpopulations.Txheeb xyuas cov ntaub ntawv los ntawm MultiSET software.Kev ntsuas tau ua raws li cov txheej txheem kev khiav haujlwm thiab cov chaw tsim khoom cov lus qhia.Siv EDTA anticoagulated ntshav sau raj los sau 2 ml ntawm cov ntshav venous.Maj mam sib tov cov qauv los ntawm tig lub raj coj mus kuaj ob peb zaug kom tsis txhob muaj qhov sib txawv.Tom qab sau cov qauv, nws raug xa mus rau qhov chaw kuaj thiab tshuaj xyuas hauv 6 teev ntawm chav tsev kub.
Immunofluorescence tsom xam: C-reactive protein (CRP) thiab procalcitonin (PCT) tau soj ntsuam tam sim tom qab ua tiav ntawm kev tshuaj ntsuam siv cov ntshav kuaj los ntawm hematology, thiab tshuaj xyuas ntawm FS-112 immunofluorescence analyzer (Wondfo Biotech Co., LTD .) kev tsom xam.) Ua raws li cov chaw tsim khoom cov lus qhia thiab cov txheej txheem kuaj.
Txheeb xyuas cov ntshav alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST) ntawm HITACHI LABOSPECT008AS tshuaj ntsuam xyuas (HITACHI).Lub sijhawm prothrombin (PT) tau txheeb xyuas ntawm STAGO STA-R Evolution analyzer (Diagnostica Stago).
Reverse transcription quantitative polymerase chain reaction (RT-qPCR): Siv RNA templates cais tawm ntawm nasopharyngeal swabs los yog qis dua cov kab mob ua pa tawm los ua RT-qPCR los kuaj SARS-CoV-2.Nucleic acids tau sib cais ntawm SSNP-2000A nucleic acid tsis siv neeg sib cais platform (Bioperfectus Technologies).Cov khoom siv kuaj pom tau muab los ntawm Sun Yat-sen University Daan Gene Co., Ltd. thiab Shanghai BioGerm Medical Biotechnology Co., Ltd. Lub voj voog thermal tau ua tiav ntawm ABI 7500 thermal cycler (Applied Biosystems).Viral nucleoside kuaj cov txiaj ntsig tau txhais tias yog qhov zoo lossis tsis zoo.
SPSS version 18.0 software tau siv los txheeb xyuas cov ntaub ntawv;Paired-sample t-test, ywj siab-sample t-test, los yog Mann-Whitney U xeem tau siv, thiab tus nqi P <.05 yog qhov tseem ceeb.
Tsib tus neeg mob hnyav thiab ob tus neeg mob hnyav tau laus dua li cov neeg nyob hauv pawg nruab nrab (69.3 vs. 40.4).Cov ntaub ntawv ntxaws ntxaws ntawm 5 tus neeg mob hnyav thiab 2 tus neeg mob hnyav tau pom nyob rau hauv Tables 1A thiab B. Cov neeg mob hnyav thiab mob hnyav feem ntau yog qis hauv T cell subsets thiab tag nrho cov lymphocyte suav, tab sis cov ntshav dawb suav yog kwv yees li qub, tshwj tsis yog rau cov neeg mob. nrog cov qe ntshav dawb siab (11.5 × 109 / L).Neutrophils thiab monocytes kuj feem ntau siab.Cov txiaj ntsig ntawm PCT, ALT, AST thiab PT ntawm 2 tus neeg mob hnyav thiab 1 tus neeg mob hnyav tau siab, thiab PT, ALT, AST ntawm 1 tus neeg mob hnyav thiab 2 tus neeg mob hnyav tau sib raug zoo.Yuav luag tag nrho 7 tus neeg mob muaj CRP siab.Eosinophils (EOS) thiab basophils (BASO) zoo li tsis tshua muaj neeg mob hnyav thiab mob hnyav (Table 1A thiab B).Table 1 teev cov lus piav qhia ntawm ib txwm muaj ntau yam ntawm hematological tsis nyob rau hauv Suav cov neeg laus.
Kev txheeb xyuas txheeb xyuas tau pom tias ua ntej kev kho mob, CD3+, CD4+, CD8+ T hlwb, tag nrho cov lymphocytes, RBC faib dav (RDW), eosinophils thiab basophils tau qis dua tom qab kho (P = .000, . 000, .000, .012, . 04, 000 thiab 001).Cov ntsuas inflammatory neutrophils, neutrophil/lymphocyte ratio (NLR) thiab CRP ua ntej kev kho mob tau nce siab dua tom qab kev kho mob (P = .004, .011 thiab .017, ntsig txog).Hb thiab RBC poob qis heev tom qab kev kho mob (P = .032, .026).PLT nce tom qab kev kho mob, tab sis nws tsis tseem ceeb (P = .183) (Table 2).
T cell subsets (CD3+, CD4+, CD8+), tag nrho cov lymphocytes thiab basophils ntawm cov neeg mob hnyav thiab mob hnyav tau qis dua cov neeg mob nruab nrab (P = .025, 0.048, 0.027, 0.006 thiab .046).Cov theem ntawm neutrophils, NLR, PCT thiab CRP hauv cov neeg mob hnyav thiab mob hnyav tau nce siab dua li cov neeg mob nruab nrab (P = .005, .002, .049 thiab .002, raws li).Cov neeg mob hnyav thiab mob hnyav tau qis dua PLT dua li cov neeg mob nruab nrab;Txawm li cas los xij, qhov sib txawv tsis yog qhov tseem ceeb (Table 3).
CD3+, CD8+, tag nrho cov lymphocytes, platelets, thiab basophils ntawm cov neeg mob hnub nyoog 50 xyoo tau qis dua cov neeg mob hnub nyoog qis dua 50 xyoo (P = .049, 0.018, 0.019, 0.010 thiab .039, raws li), thaum cov neeg laus dua. 50 xyoo Cov neeg mob 'neutrophils, NLR piv, CRP theem thiab RDW tau ntau dua li cov neeg mob hnub nyoog qis dua 50 xyoo (P = .0191, 0.015, 0.009, thiab .010, raws li) (Table 4).
COVID-19 yog tshwm sim los ntawm kev kis tus kabmob coronavirus SARS-CoV-2, uas tau tshwm sim thawj zaug hauv Wuhan, Tuam Tshoj thaum Lub Kaum Ob Hlis 2019. Tus kabmob SARS-CoV-2 tau kis sai sai tom qab ntawd thiab ua rau muaj kev sib kis thoob ntiaj teb.1-3 Vim tsis muaj kev paub txog kev kis kab mob thiab kab mob ntawm tus kab mob, qhov kev tuag ntawm tus kab mob thaum pib tshwm sim yog siab.Txawm hais tias tsis muaj tshuaj tiv thaiv kab mob, kev saib xyuas kev tswj xyuas thiab kev kho mob ntawm COVID-19 tau txhim kho zoo heev.Qhov no yog qhov tseeb tshwj xeeb tshaj yog nyob rau hauv Suav teb thaum cov kev kho mob adjuvant tau ua ke nrog cov tshuaj suav tshuaj los kho cov mob ntxov thiab nruab nrab.26 Cov neeg mob COVID-19 tau txais txiaj ntsig los ntawm kev nkag siab zoo dua ntawm cov kev hloov pauv pathological thiab kuaj ntsuas tus kab mob.kab mob.Txij thaum ntawd los, cov neeg tuag tau poob qis.Hauv tsab ntawv tshaj tawm no, tsis muaj neeg tuag ntawm 52 tus neeg mob tau txheeb xyuas, suav nrog 7 tus neeg mob hnyav thiab mob hnyav (Table 1A thiab B).
Cov kev soj ntsuam soj ntsuam tau pom tias feem ntau cov neeg mob nrog COVID-19 tau txo cov lymphocytes thiab T cell subpopulations, uas cuam tshuam txog qhov mob hnyav.13, 27 Hauv tsab ntawv ceeb toom no, nws tau pom tias CD3+, CD4+, CD8+ T hlwb, tag nrho cov lymphocytes, RDW ua ntej kev kho mob, eosinophils thiab basophils tau qis dua tom qab kev kho mob (P = .000, .000, .000, .012, .04, 000 thiab .001).Peb cov txiaj ntsig zoo ib yam li cov ntaub ntawv dhau los.Cov ntawv ceeb toom no muaj qhov tseem ceeb hauv kev saib xyuas qhov hnyav ntawm COVID-19.8, 13, 23-25, 27, thaum cov ntsuas inflammatory neutrophils, neutrophils/lymphocyte ratio (NLR) Thiab CRP tom qab kho ua ntej tshaj li kev kho mob (P = .004, . 011 thiab .017, ntsig txog), uas tau pom thiab tshaj tawm yav dhau los hauv cov neeg mob COVID-19.Yog li ntawd, cov kev txwv no raug suav tias yog cov cim qhia muaj txiaj ntsig rau kev kho mob ntawm COVID-19.8.Tom qab kev kho mob, 11 hemoglobin thiab cov qe ntshav liab tau txo qis (P = .032, 0.026), qhia tias tus neeg mob muaj ntshav tsis txaus thaum kho.Kev nce hauv PLT tau pom tom qab kev kho mob, tab sis nws tsis tseem ceeb (P = .183) (Table 2).Qhov txo qis hauv lymphocytes thiab T cell subpopulations yog xav tias muaj feem xyuam rau cell depletion thiab apoptosis thaum lawv sib sau ua ke hauv qhov chaw mob uas tawm tsam tus kab mob.Los yog, tej zaum lawv yuav tau noj los ntawm kev tso tawm ntau dhau ntawm cytokines thiab inflammatory proteins.8, 14, 27-30 Yog tias cov lymphocyte thiab T cell subsets tsis tu ncua thiab CD4 + / CD8+ piv yog siab, qhov kev cia siab tsis zoo.29 Hauv peb qhov kev soj ntsuam, lymphocytes thiab T cell subsets rov qab los tom qab kev kho mob, thiab tag nrho 52 tus neeg mob tau kho (Table 1).Cov qib siab ntawm neutrophils, NLR, thiab CRP tau pom ua ntej kev kho mob, thiab tom qab ntawd txo qis tom qab kev kho mob (P = .004, .011, thiab .017, raws li) (Table 2).Kev ua haujlwm ntawm T cell subsets hauv kev kis kab mob thiab kev tiv thaiv kab mob tau raug tshaj tawm yav dhau los.29, 31-34, ib
Raws li tus naj npawb ntawm cov neeg mob hnyav thiab mob hnyav tsawg dhau lawm, peb tsis tau ua qhov kev txheeb xyuas ntawm qhov tsis sib xws ntawm cov neeg mob hnyav thiab mob hnyav thiab cov neeg mob nruab nrab.T cell subsets (CD3+, CD4+, CD8+) thiab tag nrho cov lymphocytes ntawm cov neeg mob hnyav thiab mob hnyav yog qis dua cov neeg mob nruab nrab.Cov theem ntawm neutrophils, NLR, PCT, thiab CRP hauv cov neeg mob hnyav thiab mob hnyav tau nce siab dua li cov neeg mob nruab nrab (P = .005, .002, .049, thiab .002, raws li) (Table 3).Cov kev hloov pauv hauv chav kuaj tsis muaj feem cuam tshuam nrog qhov hnyav ntawm COVID-19.35.36 Qhov laj thawj ntawm basophilia tsis meej;Qhov no tej zaum yuav yog vim kev noj zaub mov thaum sib ntaus sib tua tus kab mob ntawm qhov chaw kis kab mob zoo ib yam li lymphocytes.35 Txoj kev tshawb nrhiav pom tias cov neeg mob uas muaj tus kab mob COVID-19 hnyav kuj tau txo eosinophils;14 Txawm li cas los xij, peb cov ntaub ntawv tsis tau qhia tias qhov tshwm sim no yuav yog vim muaj tsawg tus neeg mob hnyav thiab tseem ceeb hauv txoj kev tshawb no.
Qhov zoo siab, peb pom tias hauv cov neeg mob hnyav thiab mob hnyav, muaj kev sib raug zoo ntawm PT, ALT, thiab AST qhov tseem ceeb, qhia tias muaj ntau yam kev puas tsuaj hauv nruab nrog cev tau tshwm sim los ntawm tus kab mob tua, raws li tau hais hauv lwm qhov kev soj ntsuam.37 Yog li ntawd, tej zaum lawv yuav yog qhov tseem ceeb tshiab rau kev ntsuam xyuas cov lus teb thiab kev kwv yees ntawm kev kho mob COVID-19.
Kev soj ntsuam ntxiv tau pom tias CD3+, CD8+, tag nrho cov lymphocytes, platelets thiab basophils ntawm cov neeg mob hnub nyoog 50 xyoo tau qis dua cov neeg mob hnub nyoog qis dua 50 xyoo (P = P = .049, .018, .019, .010 thiab. 039, ntsig txog), thaum theem ntawm neutrophils, NLR, CRP, thiab RBC RDW hauv cov neeg mob hnub nyoog 50 xyoo tau nce siab dua cov neeg mob hnub nyoog qis dua 50 xyoo (P = .0191, 0.015, 0.009, thiab .010. , ntsig txog) (Table 4).Cov txiaj ntsig no zoo ib yam li cov ntaub ntawv dhau los.14, 28, 29, 38-41 Kev txo qis hauv T cell subpopulations thiab siab CD4 + / CD8 + T cell ratios muaj feem xyuam rau cov kab mob hnyav;Cov neeg laus yuav mob hnyav dua;yog li ntawd, ntau lymphocytes yuav noj nyob rau hauv lub cev tiv thaiv kab mob los yog mob hnyav.Ib yam li ntawd, qhov siab dua RBC RDW qhia tias cov neeg mob no tau tsim cov ntshav liab.
Peb cov txiaj ntsig kev tshawb fawb tau lees paub ntxiv tias qhov ntsuas hematological tseem ceeb heev rau kev nkag siab zoo dua ntawm kev hloov pauv ntawm cov neeg mob COVID-19 thiab txhawm rau txhim kho cov kev taw qhia ntawm kev kho mob thiab kev kuaj mob.
Liang Juanying thiab Nong Shaoyun sau cov ntaub ntawv thiab cov ntaub ntawv kho mob;Jiang Liejun thiab Chi Xiaowei ua cov ntaub ntawv txheeb xyuas;Dewu Bi, Jun Cao, Lida Mo, thiab Xiaolu Luo ua cov kev soj ntsuam niaj hnub;Huang Huayi yog lub luag haujlwm rau kev xav thiab sau ntawv.
Thov xyuas koj tus email rau cov lus qhia txog kev rov pib dua koj tus password.Yog tias koj tsis tau txais email hauv 10 feeb, koj tus email chaw nyob yuav tsis raug sau npe thiab koj yuav tau tsim ib tus account Wiley Online Library tshiab.
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Post lub sij hawm: Lub Xya hli ntuj-22-2021